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目的观察含吉西他滨方案治疗NK/T细胞淋巴瘤的临床疗效和毒副反应。方法 31例经病理确诊NK/T细胞淋巴瘤采用GEMOX方案(9例)或GDP方案(22例)化疗。结果 31例患者的总有效率为71.0%(22/31),主要毒副反应为骨髓抑制和胃肠道反应,其中Ⅲ、Ⅳ度白细胞减少和血小板减少发生率均为12.9%(4/31)。结论含吉西他滨方案是NK/T细胞淋巴瘤的有效治疗方案,且患者耐受性较好。
Objective To observe the clinical efficacy and side effects of gemcitabine regimen in the treatment of NK / T cell lymphoma. Methods Thirty - one patients with pathologically confirmed NK / T cell lymphoma were treated with GEMOX regimen (9 cases) or GDP regimen (22 cases). Results The total effective rate of the 31 patients was 71.0% (22/31). The main toxicities were myelosuppression and gastrointestinal reaction. The incidences of grade Ⅲ and Ⅳ leukopenia and thrombocytopenia were both 12.9% (4/31) ). Conclusion The gemcitabine-containing regimen is an effective treatment for NK / T-cell lymphoma and its patients are well tolerated.