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以乙酰乙酸乙酯为起始原料 ,经五步反应制得来氟米特 ,总收率为 43.6 % ,反应原料易得 ,反应条件温和 ,后处理方便 ,适合工业化生产。
Using ethyl acetoacetate as starting material, leflunomide was obtained through five steps. The total yield was 43.6%. The reaction raw materials were easy to obtain, the reaction conditions were mild, the post-treatment was convenient and suitable for industrialized production.