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目的探讨小剂量普奈洛尔联合5-单硝酸异山梨醇酯预防食管胃底静脉曲张破裂再出血的疗效和作用机制。方法在临床上随访2年,比较治疗组和对照组再出血的发生率。结果治疗组再出血的发生率和再出血的病死率均显著低于对照组(P<0.05)。结论小剂量普奈洛尔联合5-单硝酸异山梨醇酯预防食管胃底静脉曲张破裂再出血是安全有效的,值得临床进一步应用验证。
Objective To investigate the curative effect and mechanism of propofol combined with isosorbide 5-mononitrate on the prevention of rebleeding of esophagogastric varices. Methods The patients were followed up for 2 years clinically. The incidence of rebleeding in the treatment group and the control group was compared. Results The incidence of rebleeding and rebleeding in treatment group were significantly lower than those in control group (P <0.05). Conclusion Small dose of propranolol combined with isosorbide 5-mononitrate is safe and effective in prevention of rupture and rebleeding of esophagogastric varices. It is worth further clinical application.