利奈唑胺非肝药酶代谢,约35%以原型经肾排泄,说明书提示其浓度受其他药物影响轻微,肾功能不全患者无需调整剂量,但临床研究表明肾功能不全患者利奈唑胺所致血小板减少症或贫血发生率增高与利奈唑胺高暴露相关,且利奈唑胺与某些药物存在的相互作用可显著影响其血药浓度、利奈唑胺的血药浓度在危重症患者中个体差异大,应进行血药浓度监测。 Linezolid drug metabolism of non-liver drugs, about 35% of the prototype by the renal excretion, the instructions prompted concentration was affected by other drugs minor, patients with renal insufficiency without dose adjustment, but clinical studies have shown that patients with renal insufficiency linezolid induced platelets Increased incidence of reduced disease or anemia associated with high exposure to linezolid, and linezolid and the existence of certain drugs can significantly affect the interaction of its blood concentration, plasma concentration of linezolid in critically ill patients with large individual differences , Blood concentration should be monitored.