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目的观察早期干预对妊娠期肝内胆汁淤积症(ICP)孕妇妊娠结局的影响。方法将42例ICP孕妇随机分为两组,A组20例未实施早期干预,B组22例实施早期干预,比较两组肝功能变化及妊娠结局。结果 B组干预后血清总胆汁酸(TBA)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)水平均低于干预前(P<0.05);B组胎儿窘迫、新生儿窒息、早产及羊水粪染发生率均低于A组(P<0.05);A、B两组围生儿死亡率比较差异不显著(P>0.05)。结论对妊娠期肝内胆汁淤积症孕妇实施早期干预,可显著改善肝功能,改善妊娠结局。
Objective To observe the effect of early intervention on the pregnancy outcome of pregnant women with intrahepatic cholestasis of pregnancy (ICP). Methods Forty-two pregnant women with ICP were randomly divided into two groups. 20 cases in group A did not receive early intervention, and 22 cases in group B received early intervention. The changes of liver function and pregnancy outcome were compared between the two groups. Results The levels of serum total bile acid (TBA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBIL), direct bilirubin (P <0.05). The incidences of fetal distress, neonatal asphyxia, preterm delivery and meconium-stained amniotic fluid in group B were lower than those in group A (P <0.05) Perinatal mortality was no significant difference (P> 0.05). Conclusions Early intervention in pregnant women with intrahepatic cholestasis of pregnancy can significantly improve liver function and improve pregnancy outcomes.