目的了解急性淋巴细胞白血病(ALL)患儿停止化疗后的远期毒副反应。方法对28例长期存活5年以上的ALL 患儿进行智商、生长发育及第二肿瘤的发生情况进行分析。结果28例患儿生长发育均在正常范围,25例智商属正常,临界状态2例,智力缺陷1例,3例患儿并发了第二肿瘤。结论长程的化疗和多次三联鞘注对儿童的生长 Objective To understand the long-term toxicities and side effects of chemotherapy in children with acute lymphoblastic leukemia (ALL). Methods 28 cases of children with long-term survival of more than 5 years were analyzed for IQ, growth and development and the occurrence of the second tumor. Results The growth and development of 28 children were in the normal range. 25 cases had normal intelligence, 2 cases had critical condition, 1 case had mental retardation and 3 cases had complicated second tumor. Conclusions Long-term chemotherapy and triple triple-sheath injection on children’s growth