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目的 探讨乳腺癌组织中微血管计数与淋巴结转移、组织学分级及预后的关系。方法 对治疗后随访8年以上的乳腺癌病例,应用免疫组化S—P法,对肿瘤微血管内皮染色,作微血管计数,将其结果与影响预后的淋巴结状况、组织学分级及生存状况比较。结果 肿瘤内微血管数与淋巴结转移、组织学分级呈正相关;死亡组癌组织内微血管数明显高于存活组。结论微血管计数可做为估计乳腺癌预后和指导临床治疗的有价值的参考指标。
Objective To investigate the relationship between microvessel count and lymph node metastasis, histological grade and prognosis in breast cancer. Methods The cases of breast cancer who were followed up for more than 8 years were treated with immunohistochemical S-P method. The tumor microvascular endothelium was dyed and counted for microvessels. The results were compared with the prognosis of lymph nodes, histological grade and survival status. Results The number of microvessel in the tumor was positively correlated with lymph node metastasis and histological grade. The number of microvessel in the death group was significantly higher than that in the surviving group. Conclusion Microvessel count can be used as a valuable reference index for estimating the prognosis and guiding clinical treatment of breast cancer.