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目的:检测p53和Gadd45α蛋白在皮肤鳞状细胞癌和基底细胞癌组织中的表达。方法:应用免疫组化法对30例皮肤鳞状细胞癌和25例基底细胞癌组织中的p53和Gadd45α蛋白表达进行检测。结果:p53蛋白在皮肤鳞状细胞癌和基底细胞癌组织中的表达阳性率分别为56.67%、48%,与正常皮肤组织比较差异均有显著性(P=0.006;0.025);Gadd45α在皮肤鳞状细胞癌和基底细胞癌中表达分别为43.33%、52%,均高于正常皮肤组织的表达(P=0.031;0.010)。高分化皮肤鳞状细胞癌组阳性表达率为75%,高于中低分化组的22.22%(P=0.008)。结论:皮肤鳞状细胞癌和基底细胞癌组织中p53、Gadd45α异常表达可能参与了发病过程。
Objective: To detect the expression of p53 and Gadd45α protein in cutaneous squamous cell carcinoma and basal cell carcinoma. Methods: The expressions of p53 and Gadd45α protein in 30 cases of squamous cell carcinoma and 25 cases of basal cell carcinoma were detected by immunohistochemistry. Results: The positive rates of p53 protein in skin squamous cell carcinoma and basal cell carcinoma were 56.67% and 48%, respectively, which were significantly different from those in normal skin (P = 0.006; 0.025) The expression of Bcl-2 and Bcl-2 was 43.33% and 52%, respectively, higher than that of normal skin (P = 0.031; 0.010). The positive rate of differentiated squamous cell carcinoma was 75%, which was higher than that of moderately and poorly differentiated squamous cell carcinoma (22.22%, P = 0.008). Conclusion: The abnormal expression of p53 and Gadd45α in skin squamous cell carcinoma and basal cell carcinoma may be involved in the pathogenesis.