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目的探讨癌基因 CD_(44s)表达与人胰腺癌转移、分化、浸润的关系。方法应用免疫组化(S-P 法)技术检测人胰腺癌组织中 CD_(44s)的表达。结果人胰腺癌组织中 CD_(44s)表达在淋巴结无转移及高分化腺癌中明显地高于淋巴结有转移及低分化腺癌。结论 CD_(44s) 可做为胰腺癌分化、转移、浸润的潜在指标之一。
Objective To investigate the relationship between the expression of oncogene CD_(44s) and the metastasis, differentiation and infiltration of human pancreatic cancer. Methods The expression of CD_(44s) in human pancreatic cancer tissues was detected by immunohistochemistry (S-P). RESULTS: The expression of CD44S in human pancreatic cancer tissues was significantly higher in lymph node metastasis and well-differentiated adenocarcinoma than in lymph node metastasis and poorly differentiated adenocarcinoma. Conclusion CD_(44s) can be used as one of the potential indicators for the differentiation, metastasis and infiltration of pancreatic cancer.