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目的观察双环醇对儿童慢性乙型肝炎的疗效和安全性。方法将60例体检发现的肝功能异常的慢性乙型肝炎儿童分为两组,治疗组32例,对照组28例。治疗组用双环醇片联合苦参素片。双环醇片(百赛诺),剂量按1.5 mg/kg计算,分3次服用,苦参素片0.1 mg,3次/d。对照组单纯采用苦参素片0.1 mg,3次/d,,疗程均为24周。分别观察两组治疗前后丙氨酸氨基转移酶(ALT),天冬氨酸氨基转移酶(AST),乙肝病毒定量(HBVDNA水平)的变化。结果治疗组肝功能恢复快而明显,优于对照组。疗程结束后治疗组HBVDNA定量下降明显。结论双环醇片联合苦参素片对儿童慢性乙型肝炎是一种有效的方法,值得临床推广应用。
Objective To observe the efficacy and safety of bicyclol in children with chronic hepatitis B. Methods Sixty children with chronic hepatic dysfunction found in physical examination were divided into two groups: treatment group (32 cases) and control group (28 cases). Treatment group with bicyclic alcohol tablets combined with matrine tablets. Bicyclic alcohol tablets (Bai Sanuo), the dose according to 1.5 mg / kg calculation, taking 3 times, 0.1 mg of matrine tablets, 3 times / d. The control group was treated with oxymatrine tablets 0.1 mg three times a day for 24 weeks. The changes of ALT, AST and HBVDNA levels in two groups before and after treatment were observed. Results The liver function of the treatment group recovered quickly and obviously, which was better than that of the control group. After treatment, the treatment group HBVDNA quantitative decreased significantly. Conclusion Bicyclic alcohol tablets combined with matrine tablets in children with chronic hepatitis B is an effective method, worthy of clinical application.