丙戊酸(VPA)已成为简单的或复杂的失神发作的唯一治疗剂,而且对包括失神发作在内的多种发作类型也起辅助治疗作用。VPA治疗难治性发作的研究也早有报导。对治疗全身性发作有效,但对患严重精神发育不全的儿童,控制其病情发展疗效较佳。为此我们回顾性地研究了VPA治疗严重脑损伤病人的难治性癫癎发作的效果。 Valproate (VPA) has become the sole therapeutic agent for simple or complex absent seizures and also has adjunctive therapeutic benefits for various seizure types, including absence seizures. VPA treatment of intractable seizures have also been reported. Effective for the treatment of generalized seizures, but for children with severe mental retardation, better control of their disease progression. To this end, we retrospectively investigated the efficacy of VPA in the treatment of refractory epileptic seizures in patients with severe brain injury.