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目的观察腹膜后多次复发性脂肪肉瘤的病理形态学特点、生物学行为和鉴别诊断。方法收集了１０例腹膜后脂肪肉瘤病人的临床资料，组织切片除行ＨＥ染色外，还运用免疫组织化学ＬＳＡＢ法行Ｓ１００、肌动蛋白、波形蛋白和肌红蛋白等染色。对１０例３２个原发和复发肿瘤标本进行了大体和显微镜下观察。结果本组中６／８例原发肿瘤和１３／２４例复发肿瘤为硬化性脂肪肉瘤，其组织学特征是分化较好的梭形细胞呈束状或车轮状排列，肿瘤内含分化性脂肪肿瘤成分。本组１０例腹膜后脂肪肉瘤在２０个月～１０年间于腹膜后１～７次肿瘤复发，仅１例发生１次远处转移。本组中５例在肿瘤复发、转移过程中发生了组织学亚型的转化。结论本组中硬化性脂肪肉瘤是腹膜后脂肪肉瘤最常见的组织学亚型；腹膜后脂肪肉瘤经常局部复发，远处转移少见，反覆切除复发肿瘤可延长病人生存期。
Objective To observe the histopathological features, biological behaviors and differential diagnosis of retroperitoneal recurrent liposarcoma. Methods The clinical data of 10 patients with retroperitoneal liposarcoma were collected. In addition to HE staining, immunohistochemical LSAB method was used to stain S-100, actin, vimentin and myoglobin. Gross and microscopic observations were performed on 32 primary and recurrent tumor specimens in 10 cases. Results In this group, 6/8 primary tumors and 13/24 recurrent tumors were sclerosing liposarcomas. The histological features were well-differentiated spindle cells arranged in bundles or wheels, and the tumor contained differentiation. Fat tumor composition. This group of 10 cases of retroperitoneal liposarcoma in 20 months to 10 years after 1 to 7 times retroperitoneal tumor recurrence, only 1 case occurred 1 distant metastasis. In this group, 5 cases had histological subtype transformation during tumor recurrence and metastasis. Conclusions Sclerosing liposarcoma is the most common histological subtype of retroperitoneal liposarcomas in this group. Retroperitoneal liposarcoma often recurs locally and distant metastasis is rare. Repeated resection of recurrent tumors can prolong survival.