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炎症性肠病急性发作时,血清蛋白酶抑制物——α_2巨球蛋白的血清浓度降低.这可能是由于肠壁严重炎症和组织破坏累及蛋白酶,而蛋白水介酶大量局部释放,引起α_2巨球蛋白的消耗.本文旨在测定血浆中蛋白酶抑制物以及粪便浸出液中的血浆蛋白酶抑制物活力和蛋白酶抑制物复合物.26例住院患者按Truelove及Witts的诊断标准,都具有严重的结肠炎,直肠镜及直肠粘膜组织学检查也示有严重急性炎变.所有患者均经静脉高营养疗法及皮质类固醇治疗6天,经密切随访后分为二组.全结肠炎13例,平均年龄34岁.病变局限于直肠和远端乙结肠者13例,平均年龄24岁.所有患者经小肠双重对比造影均示正常.8例健康成人(年龄25～50岁)作对照.用免疫化学法测定α_2巨球蛋白(α_2-M)、α_1蛋白酶抑制物(α_1-PI)、抗糜蛋白酶(ACHY)、间-α-胰蛋白酶
During the acute episode of inflammatory bowel disease, the serum concentration of the serum protease inhibitor, alpha-2-macroglobulin, is reduced, probably due to the severe inflammation of the intestinal wall and the destruction of the tissue involved in proteases, which are released in large quantities and cause alpha-2 giant cells Protein consumption.The purpose of this paper is to determine plasma protease inhibitors and protease inhibitor complex in exudates from plasma and 26 inpatients with severe colitis according to the diagnostic criteria of Truelove and Witts Microscopy and rectal mucosa histological examination also showed severe acute inflammatory changes.All patients were treated by intravenous high nutrition therapy and corticosteroids for 6 days, after close follow-up was divided into two groups.The total colitis in 13 cases, the average age of 34 years. The lesions were confined to the rectum and distal colon B in 13 cases, with an average age of 24 years.All patients underwent double contrast angiography showed normal.The eight healthy adults (age 25 to 50 years) as a control. Immunocytochemistry Globulin (α_2-M), α_1-PI, anti-chymotrypsin (ACHY), α-trypsin