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本文报告用阿斯匹林治疗67例幼年类风湿性关节炎的前瞻性研究结果,病例选择按照关节炎风湿病学会幼年类风湿关节炎诊断标准委员会所制定的基本标准。患儿年龄10月～18岁。临床类型:全身型17例(25％),多关节型17例(25％),单关节型33例(50％)。阿斯匹林剂量:体重25kg以下者,按100mg/kg/日,25公斤以上者,初始剂量为每日2.4～3.6g。所有病例在服用药物7～14天后抽血测定血中水杨酸浓度。按照所测水杨酸浓度的水平,增减阿斯匹林用量以使血浓度维持在20～30mg/dl之间。对于无临床治疗反应者则增大剂量使血浓度达到35mg/dl。为了观察阿斯匹林的疗效和毒性反应,每3个月定期随访,询问病史和体格检查,测定水杨酸血浓度和SGOT随访时间平均14.7个月。
This article reports the results of a prospective study of 67 aspirin-treated juvenile rheumatoid arthritis patients selected in accordance with the basic criteria set by the Arthritis Rheumatology Society Juvenile Rheumatoid Arthritis Diagnostic Standards Board. Children aged 10 months to 18 years old. Clinical Type: 17 cases (25%) of the whole body, 17 cases (25%) of multi-joint type, 33 cases (50%) of single joint type. Aspirin dose: weight 25kg or less, according to 100mg / kg / day, 25 kg or more, the initial dose of 2.4 ~ 3.6g daily. All patients taking the drug 7 to 14 days after taking blood to determine the concentration of salicylic acid in the blood. According to the measured salicylic acid concentration levels, increase or decrease the amount of aspirin to maintain blood concentration between 20 ~ 30mg / dl. For those without clinical response, the dose was increased to achieve a blood concentration of 35 mg / dl. In order to observe the efficacy and toxicity of aspirin, regular follow-up every 3 months, history and physical examination were asked to determine the salicylic acid concentration and SGOT follow-up time an average of 14.7 months.