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标题化合物具有抑制单胺氧化酶活性,也具有优良的荧光性能。以4-卤代间苯二酚为原料,经甲酰化得到2,4-二羟基-5-卤代苯甲醛,再和吡啶乙酸乙酯经Knovengel反应合成了6种未见文献报道的吡啶香豆素类荧光化合物,通过红外光谱、核磁共振、质谱和元素分析对产物的结构进行了表征。同时研究了这些化合物的荧光性质,结果表明这些吡啶香豆素类荧光化合物荧光量子产率高、Stokes位移大,是优良的候选荧光团。
The title compounds have monoamine oxidase activity inhibition as well as excellent fluorescence properties. 4-Halogenated resorcinol was used as the starting material to form 2,4-dihydroxy-5-halogenobenzaldehyde by formylation. Six novel pyridine compounds were synthesized by Knovengel reaction with pyridine-ethyl acetate Coumarin fluorescent compounds were characterized by IR, 1H NMR, MS and elemental analysis. The fluorescence properties of these compounds were also studied. The results showed that these pyridine coumarin-based fluorescent compounds have high fluorescence quantum yield and large Stokes shift and are excellent candidate fluorophores.