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目的:评价注射用丹参(冻干)对急性基底节区脑出血患者血块吸收和改善神经功能的临床疗效。方法:选取2014年12月—2015年9月间收治的急性基底节区脑出血患者88例,按随机数字表法将其分为对照组与观察组,每组44例;对照组患者给予常规治疗,观察组患者在对照组治疗的基础上加用注射用丹参(冻干)治疗,比较两组患者治疗前和治疗14 d后的按美国国立卫生院卒中量表(NIHSS)的评分值、血肿体积和血肿周围低密度区体积,以及治疗期间两组患者不良反应的发生率。结果:治疗后两组患者的NIHSS评分值、血肿体积和血肿周围低密度区体积均低于治疗前(P<0.05),观察组患者的NIHSS评分值、血肿体积和血肿周围低密度区体积分别为(5.32±1.33)分、(8.87±3.74)m L和(5.46±2.21)m L均低于对照组为(7.86±2.08)分、(13.32±5.32)m L和(8.19±2.65)m L(P<0.05);治疗期间两组患者均未发生严重不良反应症状。结论:注射用丹参(冻干)对急性基底节区脑出血患者血块吸收和改善神经功能的效果均较为明显,促进其颅内血肿吸收,且安全性较好。
Objective: To evaluate the clinical efficacy of injection of Salvia miltiorrhiza (lyophilized) on the absorption of blood clots and the improvement of neurological function in patients with acute cerebral hemorrhage of basal ganglia. Methods: A total of 88 patients with ICH treated in our hospital from December 2014 to September 2015 were enrolled in this study. They were divided into control group and observation group according to random number table method, with 44 patients in each group. Patients in control group were given conventional The patients in the treatment group and the observation group were treated with Salvia miltiorrhiza (lyophilized) injection on the basis of the control group. The NIHSS scores of the two groups before treatment and after 14 days of treatment were compared. Volume of hematoma, volume of low density zone around hematoma, and the incidence of adverse reactions in both groups during treatment. Results: The NIHSS score, hematoma volume and the volume of low density area around hematoma were lower in both groups after treatment than those before treatment (P <0.05). The NIHSS score, the hematoma volume and the volume of low density area around hematoma in the observation group were (5.32 ± 1.33), (8.87 ± 3.74) m L and (5.46 ± 2.21) m L were lower than those in the control group (7.86 ± 2.08), (13.32 ± 5.32) m L and (8.19 ± 2.65) m L (P <0.05). No serious adverse reactions occurred in both groups during treatment. CONCLUSION: Salvia miltiorrhiza (lyophilized) injection has obvious effect on blood clot absorption and nerve function improvement in patients with acute basal ganglia cerebral hemorrhage, which promotes the absorption of intracranial hematoma and is safe.