目的:探究血清基质金属蛋白酶-8(MMP-8)、髓过氧化物酶(marrow peroxide，MPO)、人巨细胞病毒(human cytomegalovirus，HCMV)感染与缺血性脑血管病(ischemic cerebrovascular disease，ICVD)患者颈动脉粥样硬化(atherosclerosis，AS)斑块类型的关系。方法:选取2017年2月至2019年5月北大医疗康复医院确诊的90例缺血性脑血管病患者为研究组和健康体检者90例为对照组，按照超声影像学资料并参考患者颈动脉斑块类型把研究组分为不稳定斑块类型组(30例)，稳定斑块类型组(30例)以及斑块性质介于两组之间为中间类型组(30例)；另对研究组不同斑块类型患者的血清MMP-8、MPO水平及人巨细胞病毒PP65抗原(human cytomegalovirus PP65 antigen，HCMV-PP65)阳性率情况进行比较，分析它们之间的关系。结果:研究组和对照组在性别、年龄，BMI等一般资料比较，研究组血清MMP-8、MPO水平、HCMV-PP65阳性率均显著高于对照组，且差异均有统计学意义(n P<0.05)，不同斑块类型患者血清MMP-8、MPO水平及HCMV-PP65阳性率情况均有差异，随着斑块类型越不稳定，其血清MMP-8、MPO水平越高，而在中间组的HCMV-PP65阳性率高于稳定斑块组和不稳定斑块组，差异具有统计学意义(n P<0.05)。n 结论:血清MMP-8、MPO水平升高以及HVMV感染，与缺血性脑血管病患者颈动脉粥样硬化斑块类型不稳定有关，提高对颈动脉粥样硬化的认识，是控制缺血性脑血管病患者各项水平及采取及时有效的预防和治疗措施的重要环节。“,”Objective:To explore the relationship between serum matrix metalloproteinase-8 (MMP-8), myeloperoxidase (MPO), human cytomegalovirus (HCMV) infection and the type of carotid atherosclerosis in patients with ischemic cerebrovascular disease (ICVD).Methods:From February 2017 to May 2019, 90 patients with ischemic cerebrovascular disease diagnosed by Peking University Medical Rehabilitation Hospital were selected as study group and 90 healthy adult persons who underwent health checkup as control group, and the study group was divided into non-stable plaque type group (30 cases) and stable plaque type group (30 cases) according to the ultrasonic imaging data and referring to the type of carotid plaque of the patients. The patients whose plaque property were between the two groups were were enrolled as the middle type group (30 cases). The relationship between human cytomegalovirus PP65 antigen (HCMV-PP65) in the serum, MMP-8, MPO and peripheral blood white blood cells and carotid atherosclerotic plaque in patients with ischemic cerebrovascular disease was analyzed.Results:The serum MMP-8, MPO level and HCMV-PP65 positive rate in the 3 study groups were significantly higher than that of the control group (n P<0.05), and the serum MMP-8 in different plaque types groups was significantly higher in the study group and the control group than in the control group. The higher the level of MPO and the positive rate of HCMV-PP65, the higher the serum MMP-8 and MPO level in the middle plaque type group, and the positive rate of HCMV-PP65 in the middle plaque type group was higher than that of the stable plaque group and the unstable plaque group (n P<0.05).n Conclusions:The serum MMP-8, the MPO level and the HCMV infection are related to the unstable type of the carotid atherosclerosis plaque in the patients with the ischemic cerebrovascular disease, and the recognition of the carotid atherosclerosis is improved; it is an important link to control the severity of patients with ischemic cerebrovascular disease and to take timely and effective prevention and treatment measures.