论文部分内容阅读
Bedford等曾报道了一类对位取代苯基-α-羰基硫代羟肟酸-二烃胺基硫醇酯(4-RC_6H_4-COC(NOH)-S-(CH_2)_n-NR′R″)的结构及其体外重活化作用,并讨论了该类化合物肟羟基解离度、取代基的Hammitt常数等与重活化作用的构效关系。根据经典重活化理论,作者将其看成为“非季铵型重活化
Bedford et al. Have reported a class of p-substituted phenyl- alpha -carbonyl thiocroximate-dihydrocarbyl amino thiol ester (4-RC_6H_4-COC (NOH) -S- (CH_2) _n-NR’R " ) Structure and its in vitro reactivation, and the structure-activity relationship between the oxime hydroxyl group dissociation, the Hammitt constant and the reactivation of these compounds were discussed.According to the classical reactivation theory, Quaternary ammonium type reactivation