24名正常受试者,每天接受布洛芬2.400mg 和阿司匹林4g,致使布洛芬的血浓度和半衰期明显减少(P<0.001)。与阿司匹林合用后,布洛芬平均血浆浓度24小时内减少20～65%,但阿司匹林的血浓度不变。布洛芬(每天1.200或2.400mg,连续14天)合用华法令对局部凝血酶原时间、第2、7、9和12凝血因子 Twenty-four normal subjects received daily 2.400 mg of ibuprofen and 4 g of aspirin, resulting in a significant reduction in the blood concentration and half-life of ibuprofen (P <0.001). After combined with aspirin, ibuprofen average plasma concentration decreased by 20 to 65% within 24 hours, but the blood concentration of aspirin unchanged. Ibuprofen (1.200 or 2.400 mg daily for 14 consecutive days) combined with warfarin for local prothrombin time, 2, 7, 9 and 12 coagulation factors