目的：优化聚谷氨酸与表阿霉素的交联条件。方法：采用均匀实验设计，考察ａ．表阿霉素的投量（ｍｇ），ｂ．反应时间（ｈ），ｃ．反应体系的ｐＨ值对交联率的影响。结果：表阿霉素的交联率（Ｙ）在实验范围内与各因素之间符合方程：Ｙ＝７６．７０＋０．３３７８ａ－２．２８５×１０－２ｂ－８．１４１ｃ，γ＝０．９８８８。此方程在ｐＨ５．４以上适用，药物交联率最高可达到３９％。结论：本实验定量地确定了各交联条件对药物交联率的影响程度 Objective: To optimize the conditions for the cross-linking of polyglutamic acid and epirubicin. Methods: Using uniform experimental design, examine a. Epirubicin dose (mg), b. Reaction time (h), c. Effect of pH value of reaction system on crosslinking rate. Results: The epoxidation rate of epirubicin (Y) was in accordance with the equation between the experimental range and each factor: Y = 76.70 + 0.3378a-2.285 × 10-2b-8.141c, γ = 0.9888 . This equation is suitable for application above pH 5.4, and the highest rate of drug cross-linking can reach 39%. Conclusion: This experiment quantitatively determines the degree of influence of each crosslinking conditions on the rate of drug cross-linking