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用免疫组化染色和革兰染色等技术，对129例鼻咽癌、20例鼻咽粘膜慢性支进行细菌L型、EB病毒检测，同时对L型阳性、EBV阳性和L型阴性、EBV阴性组织的P21、P53表达进行对比分析。结果显示，鼻咽癌组的L型检出率为69．8％；EBV检出率为27．1％，两者有显著性差异（P＜0．05）。鼻咽癌组的P21、P53阳性表达率显著高于慢性炎组（P＜O.005）。L型阳性、EBV阳性伴P21、P53阳性的表达率也分别高于L型阴性、EBV阴性伴P21、P53阳性的表达率。表明L型、EBV感染与鼻咽癌关系密切；P21、P53过度表达与鼻咽癌的发生也有关。此外，L型和EBV感染与P21、P53的过度表达存在着相关性。提示，L型和EBV参与了P~(21)、P~(53)基因突变，并在鼻咽癌的发生中可能起协同作用。
Immunohistochemical staining and Gram staining and other techniques, 129 cases of nasopharyngeal carcinoma, 20 cases of chronic nasopharyngeal mucosal bacterial L type, Epstein-Barr virus detection, while L-positive, EBV-positive and L-negative, EBV negative Tissues P21, P53 expression comparative analysis. The results showed that the detection rate of L-type nasopharyngeal carcinoma was 69.8%; the detection rate of EBV was 27.1%, there was a significant difference between the two (P <0.05). The positive rates of P21 and P53 in nasopharyngeal carcinoma group were significantly higher than those in chronic inflammation group (P <0.05). The positive expression rates of L-positive and EBV-positive patients with P21 and P53 were also higher than that of L-negative and EBV-negative respectively. It is indicated that L-type and EBV infection are closely related to nasopharyngeal carcinoma. Overexpression of P21 and P53 is also related to the occurrence of nasopharyngeal carcinoma. In addition, L and EBV infection and P21, P53 overexpression there is a correlation. These results suggest that L-type and EBV are involved in the mutation of P ~ (21) and P ~ (53) and may play a synergistic role in the pathogenesis of NPC.