胰淀素是由胰岛β细胞分泌的一种肽类激素,具有减少进食、减轻体重、控制能量的消耗、延缓胃排空、抑制胰高血糖素分泌、舒张血管、降低血脂等作用,与代谢综合征密切相关,临床上Pramlintide(普兰林肽,人工合成的胰淀素类似物)配合胰岛素用于糖尿病的治疗已取得显著的临床药效,另外,Pramlintide的降脂作用已经成为近年来治疗肥胖的研究热点。 Amylin is a peptide hormone secreted by pancreatic β cells. It has the effects of reducing the consumption of food, reducing body weight, controlling the energy consumption, delaying gastric emptying, inhibiting the secretion of glucagon, relaxing blood vessels and lowering blood fat, Syndrome is closely related to clinically Pramlintide (pramlintide, synthetic amylin analogues) with insulin for the treatment of diabetes have achieved significant clinical efficacy, in addition, lipid-lowering effect of Pramlintide has become the treatment of obesity in recent years Research hot spots.