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目的:探讨子宫内膜异位症(EMT)患者血清中癌抗原125(CA_(125))、肿瘤坏死因子-α(TNF-α)和人附睾分泌蛋白4(HE4)的表达及其联合检测的临床意义。方法:2010年2月至2015年2月,选择EMT患者97例,作为病例组;选择同时期健康体检者120例,作为对照组。检测对照组和病例组患者治疗前血清中CA_(125)、TNF-α和HE4的水平,并计算病例组CA_(125)、TNF-α、HE4单独检测和联合检测的敏感度和特异度。结果:病例组患者血清中CA_(125)、TNF-α和HE4的水平均高于对照组(t=37.62,P<0.05;t=14.60,P<0.05;t=21.66,P<0.05);同时,随着EMT分级升高,CA_(125)、TNF-α和HE4的水平越高,Ⅲ-Ⅳ期患者均高于Ⅰ-Ⅱ期(t=14.17,P<0.05;t=5.87,P<0.05;t=14.84,P<0.05);联合检测CA_(125)、TNF-α、HE4的敏感度和特异度均高于单独检测,差异均有统计学意义(P<0.05)。结论:EMT患者血清中CA_(125)、TNF-α和HE4的水平均高于正常人群,且EMT分级越高,三项指标的表达水平越高;联合检测CA_(125)、TNF-α、HE4可提高诊断EMT的敏感度和特异度。
Objective: To investigate the expression of tumor antigen 125 (CA 125), tumor necrosis factor-α (TNF-α) and human epididymis secretory protein 4 (HE4) in patients with endometriosis (EMT) The clinical significance. Methods: From February 2010 to February 2015, 97 patients with EMT were selected as the case group. 120 healthy subjects were selected as the control group. The levels of CA 125, TNF-α and HE4 in the serum of patients in the control group and the patients in the control group before treatment were measured. The sensitivity and specificity of CA 125, TNF-α and HE 4 alone and in combination were also calculated. Results: The serum CA_ (125), TNF - α and HE4 levels of patients in the case group were significantly higher than those in the control group (t = 37.62, P <0.05; t = 14.60, P <0.05, t = 21.66, P < At the same time, the levels of CA 125, TNF-α and HE4 were higher in patients with stage Ⅲ-Ⅳ than those in stage Ⅰ-Ⅱ (t = 14.17, P <0.05; t = 5.87, P <0.05; t = 14.84, P <0.05). The sensitivity and specificity of combined detection of CA 125, TNF-α and HE4 were higher than those of the other two groups (P 0.05). Conclusion: The levels of serum CA 125, TNF-α and HE4 in patients with EMT were significantly higher than those in normal controls, and the higher the level of EMT was, the higher the levels of three indicators were. The combined detection of CA 125, TNF- HE4 can improve the sensitivity and specificity of EMT.