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采用一种管道式微反应器对2-氨基丁醇的合成进行了研究。在该反应器中,以1-硝基丙烷和甲醛原料,三甲胺为催化剂合成2-硝基丁醇。在加氢反应釜中通过加氢反应将2-硝基丁醇还原为2-氨基丁醇。考察了不同催化剂对重要中间体2-硝基丁醇合成的影响,最终选择成本低廉、易于回收的三甲胺为催化剂。在单因素条件下考察了在微反应器中不同的原料配比、保留时间对2-氨基丁醇合成的影响,并重点考察了反应的终止条件。在最优条件下,2-氨基丁醇的收率达到82.4%。
A tube-type microreactor was used to study the synthesis of 2-aminobutanol. In this reactor, 2-nitrobutyl alcohol was synthesized using 1-nitropropane and formaldehyde as raw materials and trimethylamine as a catalyst. The 2-nitrobutanol is reduced to 2-aminobutanol by a hydrogenation reaction in a hydrogenation reactor. The effects of different catalysts on the synthesis of 2-nitro-butanol, an important intermediate, were investigated. Trimethylamine, which is cheap and easy to be recovered, was finally selected as the catalyst. Under the single factor conditions, the effects of different raw materials and retention time on the synthesis of 2-aminobutanol were investigated in the microreactor, and the termination conditions of the reaction were investigated emphatically. Under the optimal conditions, the yield of 2-aminobutanol reached 82.4%.