中药缓控释制剂的体外释放行为评价一直是制约中药缓控释制剂发展的难点问题与热点问题,为从整体角度对中药复方缓控释制剂的体外释放行为进行评价,在回顾分析现有评价模式利弊的基础上,借鉴多元校正灰色分析计量原理,前瞻性地提出了基于“物质粗糙集”的中药复方缓控释制剂随方同步/异步释放行为评价模式,以合理评价制剂释放过程复方化学物质总量的动态变化特征,建立符合中药复方复杂特点的缓控释制剂释放行为评价模式。 The in vitro release behavior of traditional Chinese medicine controlled-release preparations has been a difficult problem and a hot issue restricting the development of traditional Chinese medicine controlled-release preparations. In order to evaluate the in vitro release behavior of traditional Chinese medicine controlled-release formulations from a holistic point of view, Model based on the pros and cons of multi-correction gray analysis and measurement principle, forward-looking proposed based on “material rough set ” of the controlled release compound formulation of controlled-release synchronous / asynchronous release behavior evaluation model to rational evaluation of the release process Compound chemical substances of the dynamic changes in the characteristics of traditional Chinese medicine compound to establish complex characteristics of sustained-release preparation release behavior evaluation model.