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目的：研究肿瘤坏死因子α（ＴＮＦ－α）在肝纤维化形成过程中的作用．方法：采用放射免疫分析法测定慢迁肝（ＣＰＨ）２０例，慢活肝（ＣＡＨ）２０例和５１例肝硬变（ＬＣ）患者血清ＴＮＦ－α和透明质酸（ＨＡ）含量．并分析它们的变化规律和关系．结果：ＣＡＨ，ＬＣ患者血清ＴＮＦ－α（１．１１±０．５９，０．９２±０．６６μｇ／Ｌ）含量明显高于正常对照组（０．５６±０．０８μｇ／Ｌ，Ｐ＜０．０５～０．００１）．血清ＨＡ（２１９．１±１２１．３，４４６．５±１８３．７μｇ／Ｌ）含量明显高于正常对照组（９３．Ｏ±３１．８μｇ／Ｌ，Ｐ＜０．０５～０．００１）；ＣＰＨ，ＣＡＨ患者血清ＴＮＦ－α和ＨＡ含量变化呈显著正相关（ｎ＝４０，ｒ＝０．３８４７，Ｐ＜０．０５）．结论：ＴＮＦ－α在启动和促进肝纤维化形成过程中起一定作用．
Objective: To investigate the role of tumor necrosis factor-α (TNF-α) in the process of hepatic fibrosis. Methods: The levels of serum TNF-α and HA in 20 patients with chronic hepatic failure (CPH), 20 with chronic active liver disease (CAH) and 51 with cirrhosis (LC) were determined by radioimmunoassay. And analyze their changing rules and relationships. Results: The levels of serum TNF-α (1.11 ± 0.59,0.92 ± 0.66μg / L) in CAH and LC patients were significantly higher than those in normal control group (0.56 ± 0.08μg / L, P <0 .05 ~ 0.001). The content of serum HA (219.1 ± 121.3, 446.5 ± 183.7μg / L) was significantly higher than that of the normal control group (93.0 ± 31.8μg / L, P <0.05-0.001). The levels of TNF-α and HA in CPH and CAH patients were significantly and positively correlated with each other (n = 40, r = 0.3847, P <0.05). Conclusion: TNF-α plays a role in the initiation and promotion of hepatic fibrosis.