环磷酰胺的广泛使用,特别是在治疗恶性疾病方面,已显出许多毒性作用。远期的副作用有不孕,继发性恶变和肺纤维化,而其急性副作用在少数病例注意到有抗利尿激素分泌不当和过敏反应。据我们所知,尚无关于环磷酰胺引起儿童生命危险的急性过敏反应的报道。最近,我们发现一个幼儿在静脉注射长春新碱和环磷酰胺后立即发生过敏反应。 The widespread use of cyclophosphamide, especially in the treatment of malignant diseases, has shown many toxic effects. Long-term side effects of infertility, secondary malignancies and pulmonary fibrosis, and its acute side effects in a few cases noted inappropriate anti-diuretic hormone secretion and allergic reactions. To the best of our knowledge, there are no reports of acute allergic reactions to cyclophosphamide that are life-threatening in children. Recently, we found that an infant developed anaphylactic reaction immediately after intravenous injection of vincristine and cyclophosphamide.