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目的:了解Survivin在儿童急性淋巴细胞白血病(ALL)的表达及预后意义。方法:测定了54例儿童ALL的标本,同时分析其临床特征、危险程度分类,并对所有病例进行2年的随访,并比较2年的无事生存率(EFS)。结果:ALL患者Survivin阳性41例,阴性13例,36例对照组Survivin皆为阴性。阳性组和阴性组在平均年龄、初诊时白细胞计数、肿瘤细胞百分数无统计学意义(P>0.05),但阳性组中、高危病儿明显多于阴性组,Kaplan-Meier分析,Survivin阴性的2年EFS优于Survivin阳性组(P<0.05)。结论:在儿童ALL Survivin的表达阳性病例中,中、高危病例数多,EFS时间短,预后差。
Objective: To investigate the expression and prognostic significance of Survivin in children with acute lymphoblastic leukemia (ALL). Methods: The clinical data of 54 children with ALL were analyzed. The clinical features and risk classification were also analyzed. All cases were followed up for 2 years. The 2-year EFS was also compared. Results: There were 41 cases of Survivin positive in ALL patients, 13 cases were negative, and 36 cases of control group survivin were negative. There was no significant difference between the positive group and the negative group in the mean age, the number of white blood cells and the percentage of tumor cells in the newly diagnosed group (P> 0.05). However, in the positive group, the high risk group was significantly more than the negative group, Kaplan-Meier analysis, Survivin- The annual EFS was better than Survivin positive group (P <0.05). Conclusions: Among children with positive expression of ALL Survivin, the number of middle and high risk cases is high, the EFS time is short, and the prognosis is poor.