目的:比较CHOP、CHOEP和RCHOP 3种化疗方案治疗弥漫性大B细胞淋巴瘤的疗效。方法:初治弥漫性大B细胞淋巴瘤患者25例依据化疗方案分为CHOP组7例、CHOEP组8例、RCHOP 10例,比较3组患者3年和5年生存率。结果:CHOEP组、RCHOP组3年及5年生存率均优于CHOP组(P<0.05);RCHOP组与CHOEP组3年及5年生存率比较差异无统计学意义(P>0.05)。结论:CHOEP和RCHOP方案治疗弥漫性大B细胞淋巴瘤其疗效优于CHOP方案。 OBJECTIVE: To compare the efficacy of three chemotherapy regimens of CHOP, CHOEP and RCHOP in the treatment of diffuse large B-cell lymphoma. Methods: Twenty-five patients with newly diagnosed diffuse large B-cell lymphoma were divided into CHOP group (7 cases), CHOEP group (8 cases) and RCHOP group (10 cases). The 3-year and 5-year survival rates were compared between the 3 groups. Results: The 3-year and 5-year survival rates of CHOEP group and RCHOP group were better than those of CHOP group (P <0.05). There was no significant difference in 3-year and 5-year survival rates between RCHOP group and CHOEP group (P> 0.05). Conclusion: The curative effect of CHOEP and RCHOP regimen in patients with diffuse large B cell lymphoma is better than CHOP regimen.