氧化应激是体内自由基产物超过抗氧化防御代谢时的一种不平衡状态,可导致脂质过氧化、膜蛋白损伤及DNA损害,在新生儿缺氧缺血性脑病(HIE)的再灌注损伤中可能发挥着重要作用。1990年开始,异前列烷F2a-III逐渐作为一项评定氧化应激和脂质过氧化损伤的敏感和可靠的指标,探讨其是否也可以评价HIE时脑损伤的程度,并具有一定的生物活性介导了缺氧缺血性脑损伤,有助于明确HIE的发病机制,以帮助早期诊断和治疗。 Oxidative stress is an imbalance in the production of free radical products in the body beyond antioxidant defense metabolism, leading to lipid peroxidation, membrane protein damage and DNA damage. In the reperfusion of neonatal hypoxic-ischemic encephalopathy (HIE) Injury may play an important role. Since 1990, isoprostilon F2a-III has gradually been used as a sensitive and reliable indicator to assess oxidative stress and lipid peroxidation injury, and whether it can also evaluate the extent of brain injury during HIE and has certain bioactivity Mediated hypoxic-ischemic brain injury, help to clarify the pathogenesis of HIE, to help early diagnosis and treatment.