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目的:观察厄贝沙坦对老年高血压病患者血压及心率变异性的影响。方法:140例原发性高血压患者服厄贝沙坦1次/d,共8周。治疗前和治疗8周后行24h动态心电图检查和24h动态血压监测。结果:厄贝沙坦能明显降低高压病患者的24h平均血压(P<0.01)、白昼平均血压(P<0.01)和夜间平均血压(P<0.01)。对夜间血压高于正常值的高血压病患者,厄贝沙坦能明显降低夜间血压(P<0.01),而对夜间血压已属正常者,厄贝沙坦无进一步降压作用(P>0.05),并使心率变异性时域指标SDNN、SDANN、SDNNI升高(P<0.05),频域指标HF升高(P<0.05),VLF和LF下降(P<0.05)。结论:厄贝沙坦在对老年原发性高血压患者控制血压的同时,也对改善心率变异性产生有益作用。
Objective: To observe the influence of irbesartan on blood pressure and heart rate variability in elderly patients with essential hypertension. Methods: One hundred and forty patients with essential hypertension were given irbesartan once a day for 8 weeks. 24h before treatment and 8 weeks after treatment, dynamic ECG and 24h ambulatory blood pressure monitoring. Results: Irbesartan significantly reduced 24h mean hypertension (P <0.01), mean daytime blood pressure (P <0.01) and nighttime mean blood pressure (P <0.01). Irbesartan can significantly reduce nocturnal blood pressure (P <0.01), while nocturnal blood pressure is normal in patients with hypertension with nocturnal blood pressure higher than normal. Irbesartan has no further antihypertensive effect (P> 0.05 (P <0.05), HF (P <0.05) and VLF (LF) and LF (P <0.05) in the heart rate variability time domain index (SDNN, SDANN, SDNNI) Conclusion: Irbesartan can also improve heart rate variability while controlling blood pressure in elderly patients with essential hypertension.