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本试验检测了21例肾移植病人血浆中6-酮-PGF_1α和TxB_2的浓度。结果表明,当临床出现CsA肾中毒症状前1～3天和当日,血浆中6—酮—PGF_1α水平明显降低。从而分析CsA肾中毒的发生可能是由于PGI_2降低后,使血浆中TxA_2和PGI_2的比例发生变化,TxA_2相应增加,在肾血管中微小血栓形成,使肾小球滤过率降低出现肾中毒的临床症状。我们认为在器官移植后应用CsA的病人中进行PGI_2的监测可以在临床早期发现CsA肾中毒,成为CsA肾中毒的可靠监测指标之一。
This study examined the plasma concentrations of 6-keto-PGF 1α and TxB 2 in 21 renal transplant patients. The results showed that when the clinical symptoms of CsA kidney poisoning 1 to 3 days and the day before the plasma 6-keto-PGF 1α levels were significantly lower. To analyze the incidence of CsA nephrotoxicity may be due to the PGI 2 decreased, the plasma concentration of TxA_2 and PGI_2 change, TxA_2 a corresponding increase in renal vascular micro thrombosis, glomerular filtration rate decreased renal toxicity clinical symptom. We believe that monitoring of PGI2 in CsA-treated patients after organ transplantation may lead to the discovery of CsA nephrotoxicity early in the clinic, which is a reliable indicator of CsA nephrotoxicity.