论文部分内容阅读
随着过去几十年来生物医学纳米技术和纳米材料领域的持续发展,基于纳米颗粒的药物输送系统逐渐开始有望应用于临床研究.其中,由于具有良好的生物相容性和优异的多功能负载能力,基于磁性纳米粒子的磁性药物传递系统受到越来越多的关注.本综述首先总结了磁性药物传递系统的基本物理化学性质,以阐明磁性药物传递系统需要保持适当的性能以满足特定的临床需要;其次,讨论了在设计未来临床应用的磁性药物传递系统时的表面修饰和功能化问题;最后,重点综述了磁性纳米颗粒、磁性组装体以及磁性微泡、磁性脂质体和生物膜修饰的磁性载体系统的设计和制备最新进展.最后,本综述对目前研究的磁性载体系统的设计、制备和安全性进行了总结,并对未来进一步解决磁性药物传递系统的临床应用瓶颈和前景进行了展望.
With the continuous development of biomedical nanotechnology and nanomaterials in the past decades, nanoparticle-based drug delivery systems are gradually beginning to be applied in clinical research, among which, due to their good biocompatibility and excellent multi-function loading ability , Magnetic nanoparticle-based magnetic drug delivery systems are gaining more and more attention.This review first summarizes the basic physico-chemical properties of magnetic drug delivery systems to demonstrate that magnetic drug delivery systems need to maintain proper performance to meet specific clinical needs Secondly, we discussed the surface modification and functionalization in the design of magnetic drug delivery systems for future clinical applications. Finally, we focused on magnetic nanoparticles, magnetic assemblies, and magnetic microbubbles, magnetic liposomes and biofilm modified Magnetic carrier system design and preparation of the latest progress.Finally, this review summarizes the current design of the magnetic carrier system design, preparation and safety, and to further solve the clinical application of magnetic drug delivery system bottlenecks and prospects of the future .