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以小鼠化学性交感神经末梢损伤、家兔尺神经机械损伤为模型及用新生大鼠背根神经节体外无血清培养法，研究神经生长因子（ＮＧＦ）对周围神经损伤及感觉神经元的保护作用。结果表明，ＮＧＦ剂量依赖地提高小鼠颌下腺去甲肾上腺素残留率，提高损伤后兔Ｃ７，Ｔ１背根神经节的细胞数，显著促进新生大鼠背根神经节突起的生长。结果提示，ＮＧＦ对周围神经损伤有明显的保护作用，并对感觉神经元有很强的神经营养作用。
The effects of nerve growth factor (NGF) on the injury of peripheral nerves and the sensory neurons were studied by chemical sympathetic nerve endings injury in mice, mechanical damage of ulnar nerve in rabbits and the in vitro serum-free culture of neonatal rat dorsal root ganglion effect. The results showed that NGF dose-dependently increased the residual rate of norepinephrine in the submandibular gland of rats and increased the number of dorsal root ganglion (C7) and dorsal root ganglion (T1) in rabbits. It significantly promoted the growth of dorsal root ganglion neurons in neonatal rats. The results suggest that NGF has a significant protective effect on peripheral nerve injury and has a strong neurotrophic effect on sensory neurons.