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目的探讨T2DM合并下肢动脉病变(PAD)患者血清缺血修饰白蛋白(IMA)的变化与意义。方法测定T2DM患者踝肱指数(ABI)筛查PAD,以ABI<0.9或≥1.3为界点分为PAD组(n=70)和非PAD组(n=117),分析两组在IMA及代谢参数方面的差异,探讨IMA与代谢参数相关性,并分析PAD的危险因素。结果 PAD组的糖尿病病程、HbA1c、UAlb、胰岛素抵抗指数(HOMA-IR)高于非PAD组,PAD组IMA水平显著低于非PAD组(P<0.05);IMA与HbA1c呈负相关,与其他参数无相关性。Binary logistic回归分析显示,糖尿病病程、HbA1c、UAlb及IMA为PAD危险因素或危险标志物。结论 PAD患者血清IMA降低,IMA与HbA1c呈负相关;IMA为PAD的危险标志物。
Objective To investigate the changes and significance of serum ischemia-modified albumin (IMA) in T2DM patients with lower extremity arterial disease (PAD). Methods The ankle brachial index (ABI) of T2DM patients were screened for PAD. The patients were divided into PAD group (n = 70) and non-PAD group (n = 117) with ABI <0.9 or ≥1.3. Parameters, to explore the correlation between IMA and metabolic parameters, and analyze the risk factors of PAD. Results The duration of diabetes, HbA1c, UAlb and HOMA-IR in PAD group were significantly higher than those in non-PAD group (P <0.05). There was a negative correlation between IMA and HbA1c, No correlation of parameters. Binary logistic regression analysis showed that the duration of diabetes, HbA1c, UAlb and IMA were risk factors or risk markers for PAD. Conclusions Serum IMA decreased in PAD patients and IMA was negatively correlated with HbA1c. IMA was a risk marker for PAD.