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目的:该文利用腮腺的动态显像研究调强适形放疗加卡莫氟增敏治疗鼻咽癌对腮腺功能的保护作用。方法:将71例II~III期鼻咽癌患者分成对照组和实验组两组,对照组用普通适形放疗,实验组配合调强适形放疗加卡莫氟口服,并分别于放疗开始前、放疗开始后1个月、放疗结束时及放疗结束后4、8、12个月作口干程度的比较及腮腺99mTc核素显像定量监测。结果:放疗结束时两组均出现不同程度的口干症状,但放疗结束后8个月时实验组患者口干症状开始有明显改善,至放疗结束后1年时绝大多数患者已无明显口干症状,腮腺定量分析摄取指数(UI)和分泌指数(EI)均显著高于对照组(P<0.01)。结论:调强适形放疗加卡莫氟增敏治疗鼻咽癌,对腮腺功能具有较好的保护作用。
Objective: In this study, the dynamic imaging of the parotid gland was used to study the protective effect of strengthening conformal radiotherapy plus carboplatin on the parotid gland function in nasopharyngeal carcinoma. Methods: 71 patients with stage II-III nasopharyngeal carcinoma were divided into two groups: control group and experimental group. The control group was treated with common conformal radiotherapy. The experimental group was treated with intensity-modulated conformal radiotherapy plus carbofluoride orally. Before the start of radiotherapy , One month after the start of radiotherapy, the end of radiotherapy and radiotherapy 4,8,12 months after the degree of dry mouth and parotid gland 99mTc scintigraphy quantitative monitoring. Results: At the end of radiotherapy, both groups had different degrees of dry mouth symptoms, but the experimental group had marked improvement in the symptoms of dry mouth at 8 months after the end of radiotherapy. Most of the patients had no obvious mouth at 1 year after the end of radiotherapy Dry symptom, parotid gland quantitative analysis of the index of intake (UI) and secretion index (EI) were significantly higher than the control group (P <0.01). CONCLUSION: IMRT plus carboplatin sensitization in the treatment of nasopharyngeal carcinoma has a good protective effect on parotid gland function.