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目的：进一步探讨加味射麻汤的作用机理。方法：采用放射免疫分析法，观察其对实验性过敏性哮喘豚鼠治疗前后血浆ｃＡＭＰ、ｃＧＭＰ含量变化的影响。结果：哮喘豚鼠经用该药治疗 ８天后与模型组比较，能显著升高血浆 ＣＡＭＰ含量（Ｐ＜ ０． ０１）和 ｃＡＭＰ／ｃＧＭＰ比值（ Ｐ＜ ０．０１），并能显著降低 ｃＧＭＰ含量（Ｐ＜０．０１）。结论：加味射麻汤的作用机理与调节环核苷酸水平有关，此为临床用药提供了分子药理学依据。
Objective: To further explore the mechanism of Jiawei Shema Decoction. METHODS: Radioimmunoassay was used to observe the effects of plasma cAMP and cGMP levels on the allergic asthma guinea pigs before and after treatment. RESULTS: Compared with the model group, asthmatic guinea pigs could significantly increase plasma CAMP levels (P<0.01) and cAMP/cGMP ratio (P<0.01) after 8 days of treatment with the drug, and significantly reduce the cGMP content (P<0.01). P<0.01). Conclusion: The mechanism of action of Jiawei Shema Decoction is related to the regulation of cyclic nucleotide levels, which provides molecular pharmacology basis for clinical drug use.