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本文给大、小白鼠注射~(75)Se-亚硒酸钠,研究了硒的药物动力学变化及各种因素的影响。结果表明:硒在大、小鼠体内的药物动力学符合二室开放模型,不同给药途径无明显影响;硒经胃吸收良好,体内分布以肝肾最高,其次为血液、肺、脾、胃肠、心脏等。机体摄入多量以至中毒量硒以后,各组织通过延缓吸收、增加排泄来缓解硒浓度,过量未排泄的硒则进入血细胞内储存。给低硒动物硒制剂后,各组织通过加快吸收,延缓排泄而有效地保留硒。本实验阐明了硒的代谢动力学规律,为硒的临床应用提供了实验依据。
In this paper, large and white mice were injected with ~ (75) Se-sodium selenite to study the changes of selenium pharmacokinetics and the influence of various factors. The results showed that the pharmacokinetics of selenium in large mice and mice were in accordance with the two-compartment open model and had no obvious effect in different routes of administration. Selenium was well absorbed by the stomach, with the highest liver and kidney distribution in the body, followed by blood, lung, spleen and stomach Intestine, heart and so on. After ingesting large amount of organism and poisoning selenium, all tissues can relieve the selenium concentration by delaying the absorption and increasing the excretion, and the selenium that is not excreted in excess enters the blood cell storage. Selenium to low-selenium animals, the organizations through the accelerated absorption, delay excretion and effectively retain selenium. This experiment clarified the rule of the metabolic kinetics of selenium and provided the experimental basis for the clinical application of selenium.