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目的探讨初治急性淋巴细胞白血病(ALL)中P-糖蛋白(P-gp)与细胞表面分化抗原表达的关系及意义。方法应用流式细胞术对64例初治ALL患者进行P-gp及免疫表型的检测。结果 P-gp的阳性表达率为45.3%,CD34为59.4%,My+ALL为31.3%,其中CD13阳性率最高,为20.3%。P-gp与预后呈负相关(P<0.05),CD34+、My+ALL与CD34-、My-ALL的CR率差异均无统计学意义(P>0.05)。P-gp+组中CD34的表达显著高于P-gp-组(P<0.05),其他中晚期抗原表达差异无统计学意义。P-gp与CD34协同表达则CR率更低(52.2%vs90.0%)。结论 P-gp的表达在初治ALL患者中具有重要的预后意义。P-gp的过度表达与CD34有关,P-gp+/CD34+的ALL属于一种预后不良的临床亚型。
Objective To investigate the relationship between the expression of P-glycoprotein (P-gp) and differentiation of cell surface antigen in newly diagnosed acute lymphoblastic leukemia (ALL). Methods Flow cytometry was used to detect P-gp and immunophenotype in 64 newly diagnosed ALL patients. Results The positive rate of P-gp was 45.3%, that of CD34 was 59.4%, and that of My + ALL was 31.3%. The positive rate of CD13 was 20.3%. P-gp was negatively correlated with prognosis (P <0.05). There was no significant difference in CR rates between CD34 +, My + ALL, CD34- and My-ALL (P> 0.05). The expression of CD34 in P-gp + group was significantly higher than that in P-gp-group (P <0.05). There was no significant difference in other middle and late antigen expression. The co-expression of P-gp with CD34 resulted in a lower CR rate (52.2% vs 90.0%). Conclusion The expression of P-gp has important prognostic significance in newly diagnosed ALL patients. Overexpression of P-gp is associated with CD34, and ALL with P-gp + / CD34 + is a poor prognostic clinical subtype.