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目的探讨异基因造血干细胞移植治疗儿童血液病的价值。方法采用异基因造血干细胞移植治疗11例儿童血液病,其中再生障碍性贫血2例、白血病7例、骨髓异常增生症1例、非霍奇金淋巴瘤1例;预处理采用氟达拉滨/环磷酰胺(FLU/CTX)或全身放疗/环磷酰胺(TBI/CTX),观察患儿的临床治疗效果。结果10例患儿均移植成功,9例患儿生存,其中7例无病存活,存活最长时间为5.5年;CMV感染3例,继发出血性膀胱炎1例,继发弥漫性GVHD1例。结论异基因造血干细胞移植是治疗儿童血液病的有效方法,值得临床进一步推广。
Objective To investigate the value of allogeneic hematopoietic stem cell transplantation in the treatment of hematological diseases in children. Methods Allogeneic hematopoietic stem cell transplantation was used to treat 11 children with hematologic diseases, including 2 aplastic anemia, 7 leukemia, 1 myelodysplastic syndrome and 1 non-Hodgkin’s lymphoma. Pretreatment with fludarabine / Cyclophosphamide (FLU / CTX) or systemic radiotherapy / cyclophosphamide (TBI / CTX), to observe the clinical treatment of children. Results All the 10 cases were successfully transplanted, and 9 cases survived. Among them, 7 cases survived without disease and the longest survival time was 5.5 years. CMV infection in 3 cases, secondary hemorrhagic cystitis in 1 case and secondary diffuse GVHD in 1 case. Conclusion Allogeneic hematopoietic stem cell transplantation is an effective method for the treatment of children’s hematological diseases and deserves further clinical promotion.