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目的探讨普通人群肝脏硬度测量值(LSM)与受控衰减参数(CAP)之间的关联,为临床研究提供参考。方法在207例成功进行FibroScan检查的健康体检者,获取性别、年龄、体质量指数(BMI)和腰高比(WHtR)资料,分析其LSM和CAP的相关性。结果不同年龄人群LSM的差异无统计学意义,但在BMI≥24 kg/㎡的受试者,其LSM和CAP值分别为(4.60±1.15)kPa和(245.24±55.37)dB/m,均显著高于BMI<24 kg/㎡的受试者[(4.25±1.23)kPa和(215.82±55.47)dB/m,P<0.001];WHtR≥0.50的受试者LSM和CAP分别为(4.52±1.22)kPa和(247.04±57.78)dB/m,亦均高于WHtR<0.50的受试者[(4.19±1.15)kPa和(204.65±52.25)dB/m,P<0.05];男性受试者LSM和CAP值亦均高于女性受试者[(4.53±1.23)kPa和(4.11±1.08)dB/m对(4.11±1.08)kPa和(220.08±57.88)dB/m,P<0.05];年龄≥50岁的受试者CAP值[(246.56±59.06)dB/m]高于年龄<50岁的受试者[(222.88±56.60)dB/m];LSM与CAP值呈显著性正相关(r=0.26,P=0.0002);进一步对各组人群分析发现,在BMI≥24 kg/㎡、WHtR>0.50、男性受试者和年龄≥50岁的受试者中,LSM与CAP值呈显著性正相关(P<0.05),其中在BMI≥24 kg/㎡组人群,两者呈非常显著性正相关(r=0.37,P<0.01);通过相关分析发现,LSM和CAP均与BMI、WHtR和性别相关(P<0.05);通过偏相关分析发现,LSM与CAP参数之间呈显著性正相关(r=0.20,P=0.0045);在体质量指数≥24 kg/㎡的超重或肥胖的受试者中,肝脏硬度值和受控衰减参数的相关性更强(r=0.37,P=0.0003)。结论普通人群LSM与CAP均受BMI、WHtR和性别的影响,并且两个参数之间表现出一定的正相关,其相关存在的确切原因有待于进一步研究。
Objective To investigate the correlation between LSM and controlled decay parameters (CAP) in the general population, and provide a reference for clinical research. Methods Totally 207 healthy subjects who underwent FibroScan were enrolled in this study. Gender, age, body mass index (BMI) and waist-to-hip ratio (WHtR) data were obtained and the correlation between LSM and CAP was analyzed. Results There was no significant difference in LSM between different age groups, but the LSM and CAP values were (4.60 ± 1.15) kPa and (245.24 ± 55.37) dB / m in subjects with BMI≥24 kg / ㎡, respectively (4.25 ± 1.23) kPa and (215.82 ± 55.47) dB / m, P <0.001 for subjects with BMI <24 kg / m 2; LSM and CAP for subjects with WHtR ≥ 0.50 were (4.52 ± 1.22 ), kPa and (247.04 ± 57.78) dB / m, respectively, were also higher than those with WHtR <0.50 [(4.19 ± 1.15) kPa and (204.65 ± 52.25) dB / m, respectively; And CAP values were also higher than those in female subjects [(4.53 ± 1.23) kPa and (4.11 ± 1.08) dB / m vs 4.11 ± 1.08 kPa and (220.08 ± 57.88) dB / m, respectively CAP values in subjects over 50 years of age were (246.56 ± 59.06) dB / m higher than those of subjects <50 years of age (222.88 ± 56.60) dB / m; LSM was positively correlated with CAP ( r = 0.26, P = 0.0002); Further analysis of each group of people found that in the BMI â ‰ ¥ 24 kg / ㎡, WHtR> 0.50, male subjects and subjects aged ≥50 years, LSM and CAP values were significantly (P <0.05). There was a significant positive correlation between the two groups (r = 0.37, P <0.01) in the population with BMI≥24 kg / m 2. Correlation analysis showed that LSM and CAP were positively correlated with BMI, WHtR is gender related (P <0.05). By partial correlation analysis, there was a significant positive correlation between LSM and CAP parameters (r = 0.20, P = 0.0045); in overweight or obese subjects with body mass index ≥24 kg / m The correlation between liver hardness values and controlled attenuation parameters was stronger (r = 0.37, P = 0.0003). Conclusion Both LSM and CAP in the general population are affected by BMI, WHtR and gender, and some positive correlations exist between the two parameters. The exact reason for its existence needs to be further studied.