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目的:观察奥沙利铂加醛氢叶酸(LV)和大剂量氟尿嘧啶(5Fu)持续48小时滴注(双周疗法)治疗大肠癌的疗效和毒性。方法:31例晚期大肠癌患者,均为术后有残留病灶或复发转移不能切除的有可测量病灶的患者,静脉滴注奥沙利铂100mg/m2,LV200mg/m2,LV滴注之后用5Fu0.5g静推,接着用5Fu3.0g/m2持续48小时静脉滴注,2周重复,4周为周期。结果:31例可测量实体病灶的患者,平均疗程数为3.62个,其中CR2例,PR14例,SD11例和PD4例,近期有效率(CR+PR)为51.6%。结论:奥沙利铂加LV/5Fu方案疗效高,毒副作用小,患者容易耐受,值得推广使用。
Objective: To observe the curative effect and toxicity of oxaliplatin combined with alformin (LV) and high-dose 5Fu for 48 hours drip (biweekly therapy) for colorectal cancer. Methods: Thirty-one patients with advanced colorectal cancer were patients with measurable lesions who could not be resected with residual or postoperative recurrence. Patients were given oxaliplatin 100 mg / m 2 and LV 200 mg / m 2 intravenously, then treated with 5Fu0 .5g static push, followed by 5Fu3.0g / m2 intravenous infusion for 48 hours, two weeks repeated, four weeks for the cycle. Results: The average number of courses of treatment for 31 patients with measurable physical lesions was 3.62, of which CR2, PR14, SD11 and PD4 had the best response rate (CR + PR) of 51.6%. Conclusion: The oxaliplatin plus LV / 5Fu regimen has high curative effect, small toxic and side effects, and the patients are easy to tolerate. It is worth promoting.