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目的观察两种高效抗逆转录病毒治疗(HAART)方案治疗后艾滋病患者空腹血糖的动态变化。方法收集2012年1月—2015年12月在贺州市人民医院行HAART治疗的艾滋病患者400例,按照用药方案不同分为A组(TDF+3TC+EFV)和B组(AZT+3TC+EFV),检测治疗前和治疗后1、3、6、12个月空腹血糖和治疗前及治疗后CD4+T淋巴细胞计数以及治疗期间并发症发生情况。结果 A组和B组治疗前空腹血糖分别为(5.31±0.48)mmol/L和(5.35±0.60)mmol/L,差异无统计学意义(P>0.05)。A组和B组治疗后1、3、6、12个月空腹血糖分别为(5.76±0.59)mmol/L和(5.67±0.69)mmol/L、(5.94±0.73)mmol/L和(5.73±0.59)mmol/L、(5.98±0.71)mmol/L和(5.81±0.66)mmol/L、(5.92±0.62)mmol/L月和(5.97±1.06)mmol/L,A组和B组治疗后空腹血糖均明显高于治疗前(P<0.05);3个月和6个月的空腹血糖两组间的差异有统计学意义(P<0.05),而1个月和12个月的空腹血糖两组间的差异无统计学意义(P<0.05)。结论 TDF+3TC+EFV和AZT+3TC+EFV均可使艾滋病患者空腹血糖水平升高,且升高程度相当。
Objective To observe the dynamic changes of fasting blood glucose (FBG) in AIDS patients after treatment with two highly active antiretroviral (HAART) regimens. Methods 400 cases of AIDS patients who were treated with HAART from January 2012 to December 2015 in Hezhou People’s Hospital were divided into group A (TDF + 3TC + EFV) and group B (AZT + 3TC + EFV) The fasting blood glucose, pre-treatment and post-treatment CD4 + T lymphocyte counts and the complications during and after treatment were detected before treatment and at 1,3,6,12 months after treatment. Results The fasting blood glucose in group A and group B before treatment was (5.31 ± 0.48) mmol / L and (5.35 ± 0.60) mmol / L, respectively, with no significant difference (P> 0.05). The fasting blood glucose of group A and group B were (5.76 ± 0.59) mmol / L and (5.67 ± 0.69) mmol / L, (5.94 ± 0.73) mmol / L and 0.59 mmol / L, 5.98 ± 0.71 mmol / L, and 5.81 ± 0.66 mmol / L, 5.92 ± 0.62 mmol / L and 5.97 ± 1.06 mmol / L, respectively Fasting blood glucose were significantly higher than before treatment (P <0.05); 3-month and 6-month fasting blood glucose differences between the two groups were statistically significant (P <0.05), while 1 month and 12 months of fasting blood glucose There was no significant difference between the two groups (P <0.05). Conclusions TDF + 3TC + EFV and AZT + 3TC + EFV can increase the level of fasting blood glucose in AIDS patients with the same increase.