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为验证内生致冷原(EC)能否影响内毒素(ET)性发热第二热相或热限水平,并确实脑脊液中cAMP水平是否与EC的降温作用有关,作者用90只新西兰兔进行实验。观察:①输注人尿或等量生理盐液对正常家免体温的影响,检测EC效应期血浆和脑脊液中cAMP的含量;②在第二热峰出现前输注人尿或生理盐液对第二热相的影响,检测EC效应期血浆及脑脊液中cAMP的含量。结果表明:①人尿明显降低正常家兔的直肠温度,而等量生理盐液则无此作用,且两者均引起血浆及脑脊液中cAMP浓度的明显下降,提示EC的降温作用与脑cAMP浓度下降可能无重要关系;②人尿(EC)抑制ET性发热第二热相的形成,从而降低热限水平,变双相热为单相热,同量生理盐水无此作用,两者都能降低血浆和脑脊液中cAMP的水平,但EC不及NS明显,表明EC抑制第二热相或降低热限水平的作用也与cAMP浓度变化无重要关系,作者推论cAMP不是ET性发热第二热相的唯一成因。
To verify whether endogenous pyrogen (EC) could affect the second thermal phase or heat limit level of endotoxin (ET) fever and whether CSF levels of cAMP correlated with the cooling effect of EC, 90 New Zealand rabbits experiment. Observe: ①influence of human urine or equivalent physiological saline on normal body temperature, detect the content of cAMP in plasma and cerebrospinal fluid in EC effect period; ②inject human urine or physiological saline before the appearance of second heat peak The second hot phase, the detection of EC effect of plasma and cerebrospinal fluid levels of cAMP. The results showed that: (1) Human urine significantly reduced the rectal temperature of normal rabbits, while the same amount of physiological saline did not, and both of them caused a significant decrease of cAMP concentration in plasma and cerebrospinal fluid, suggesting that the cooling effect of EC and brain cAMP concentration Decline may not have an important relationship; ② human urine (EC) inhibits the formation of the second heat phase of ET fever, thereby reducing the heat level, variable biphasic heat single-phase heat, with the same amount of normal saline without this effect, both Reduce the level of cAMP in plasma and cerebrospinal fluid, but the EC is not as obvious as that of NS, indicating that the effect of inhibiting the second heat phase or decreasing the heat limit level with EC is also irrelevant to the change of cAMP concentration. The authors conclude that cAMP is not the second heat phase of ET fever The only reason.