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甲胎蛋白是胎儿时期肝细胞产生的一种蛋白,出生后一周即消失,当肝细胞恶性变之后,又重新获得合成此种蛋白的能力,故除孕妇及新生儿外,在原发性肝癌、少数睾丸或卵巢的胚胎性癌患者中可检得此种蛋白。因此对确定原发性肝癌的诊断极有帮助。所以人们一般印象AFP升高≥500ng/ml者就诊断肝癌,但实际上肝病升高的也不少见,故引起人们的普遍注意。因测定甲胎蛋白的方法较多,现以火箭电泳自显影法为例(正常25ng/ml以下),有人测定483例肝病患者的AFP,其中110例阳性,占23.0%。急性无黄疸肝炎(急无黄肝)阳性者占2.2%,急黄肝占19.8%,慢迁肝占19.9%,慢活肝占34.4%,肝硬化占44.6%,各类重肝占52.6%。
Alpha-fetoprotein is a protein produced by fetal liver cells during the first week after birth disappears, when the malignant change of liver cells, and regained the ability to synthesize such proteins, it is pregnant and newborns, in addition to primary liver cancer A small number of testicular or ovarian embryonal carcinoma patients can detect this protein. Therefore, the diagnosis of primary liver cancer is extremely helpful. Therefore, people generally diagnose AFP increased ≥ 500ng / ml on the diagnosis of liver cancer, but in fact the liver disease is not uncommon, it caused widespread attention. For the determination of alpha-fetoprotein method is more rocket electrophoresis autoradiography (normal 25ng / ml below), was measured in 483 patients with liver disease AFP, of which 110 cases were positive, accounting for 23.0%. Acute jaundice hepatitis accounted for 2.2%, acute yellow liver accounted for 19.8%, chronic liver accounted for 19.9%, slow living liver accounted for 34.4%, liver cirrhosis accounted for 44.6%, various types of liver accounted for 52.6% .