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细胞凋亡是由基因编程控制的细胞主动参与的自杀过程,促凋亡基因缺失或受抑制,将会导致肿瘤的发生和恶化,抗凋亡基因的活化和高表达也会促进肿瘤的发生和发展,导致预后不良。Survivin(生存蛋白或生存素)是凋亡抑制蛋白(IAP)家族的成员之一,1997年由耶鲁大学Ambrosini等经效应细
Apoptosis is a process of suicide committed by cells programmed by gene programming. The deletion or suppression of pro-apoptotic genes will lead to the occurrence and deterioration of tumors. Activation and high expression of anti-apoptotic genes will also promote tumorigenesis Development, leading to poor prognosis. Survivin (Survivin or Survivin) is a member of the apoptosis-inhibitory protein (IAP) family.