本文测定了慢性常压缺氧（Ⅱ组）、缺氧伴ＣＯ－２潴留（Ⅲ组）及对照组（Ⅰ组）大鼠红细胞变形能力与红细胞膜收缩蛋白二聚体（ＳＰ－Ｄ）和四聚体（ＳＰ－Ｔ）的相对含量。结果表明，Ⅱ、Ⅲ组红细胞变形指数（ＤＩ）和ＳＰ－Ｄ、ＳＰ－Ｔ相对含量与Ⅰ组均有显著差异，且Ⅱ、Ⅲ组的ＤＩ与ＳＰ－Ｄ／ＳＰ－Ｔ比值呈显著负相关。提示膜收缩蛋白的异常，可能是导致慢性缺氧和伴ＣＯ－２潴留大鼠红细胞变形能力降低的重要因素之一。 In this paper, the relationship between erythrocyte deformability and erythrocyte membrane-shrinkage protein dimer (SP-D), chronic bronchitis and hypoxemia (groupⅡ), hypoxia with CO_2 retention (group Ⅲ) and control group Tetramer (SP-T) relative content. The results showed that the relative contents of DI, SP-D and SP-T in group Ⅱ and group Ⅲ were significantly different from those in group Ⅰ, and the DI and SP-D / SP-T ratios in group Ⅱ and Ⅲ were significantly negative Related. Suggesting that abnormalities of membrane contractile proteins may be one of the important factors leading to the decrease of erythrocyte deformability in chronic hypoxia and rats with CO-2 retention.