The chronic infection of hepatitis B virus (HBV) is the major cause of hepatocellular carcinoma (HCC) globally[1]. In Eastern China, chronic HBV infection contributes to 87.5％ of HCC whereas chronic hepatitis C virus (HCV) infection contributes to 1.7％[2]. The mortality of HCC has increased in Europe and America over recent decades[3]. Although the infection of HCV is the leading cause of HCC in most European and American countries, the contribution of HBV is increasing possibly due to immigration[3].