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[目的]探讨血清可溶性晚期糖基化终末产物受体 (sRAGE)水平在多囊卵巢综合(PCOS)患者中的表达及临床意义.[方法]选取2015年1月至2016年4月于本院生殖中心就诊的PCOS患者80例,依据伴或不伴高雄激素血症(HA)/胰岛素抵抗(IR),将PCOS患者分为四组.A组:PCOS+不伴高雄激素血症(NHA)+不伴高胰岛素抵抗(NIR);B组:PCOS+IR;C组:PCOS+HA;D组:PCOS+HA+IR,每组20例.另选20名健康女性为正常对照组(E组).采用电化学发光法检测各组黄体生成激素(LH)、睾酮(T)和空腹胰岛素(fasting blood insulin,FINS)、己糖激酶法检测空腹血糖(fasting blood glucose,FBG)、ELISA法检测血清sRAGE水平,用稳态模式胰岛素抵抗指数(HOMA-IR)评价IR程度.分析sRAGE与各指标的相关性.[结果]sRAGE值由高到底分别是E组、A组、C组、B组、D组(P<0.05),组间比较差异有统计学意义(P<0.05);sRAGE与LH、T、FBG、FINS、HOME-IR呈负相关.[结论]sRAGE可通过竞争性结合RAGE的配体,减弱其所导致的病理作用,在PCOS中起潜在保护作用.“,”[Objective]To investigate the expression of solube receptor for advanced glycation end products (sRAGE) in patients with polycystic ovary syndrome (PCOS) and its clinical significance.[Methods] From January 2015 to April 2016, 80 patients with PCOS were enrolled in the reproductive center of our hospital.PCOS patients were divided into four groups according to whether or not accompanied by hyperandrogenism / insulin resistance (IR).Group A: PCOS+ without NHA + without high insulin resistance (NIR);Group B: PCOS+IR;Group C: PCOS+HA;Group D: PCOS+HA+IR, 20 cases in each group.20 healthy women were selected as the normal control group (group E).The levels of luteinizing hormone (LH), testosterone (T) and fasting insulin (FINS) were detected by electrochemiluminescence assay, Fasting serum glucose (fasting, blood, glucose, FBG) and ELISA were used to detect serum sRAGE levels by sugar kinase method;the degree of IR was evaluated by HOMA-IR.The correlation between sRAGE and indexes was analyzed.[Results]sRAGE value from high to the bottom were group E, group A, group C, group B, group D (P<0.05), the difference between the two groups was statistically significant (P<0.05);sRAGE was negatively related to LH, T, FBG, FINS and HOME-IR.[Conclusion]sRAGE can combine with the ligand of RAGE competitively , weaken the pathological role caused, has potential protective effect in PCOS.