目的研究原发性肠非霍奇金淋巴瘤的病理形态及临床特点，分析其临床误诊原因。方法回顾分析２０例原发性肠非霍奇金淋巴瘤的临床资料，并行常规病理学检查及部分免疫组织化学染色。结果本组中男１３例，女７例。平均年龄３７．９岁，２０－４０岁者占５０％，发病部位以结肠和盲肠居多，术前仅３例得以确诊。病理分类Ｔ细胞性６例，Ｂ细胞性１４例，其中２例为肠病相关性Ｔ细胞性淋巴瘤，４例为粘膜相关性Ｂ细胞性淋巴瘤。结论原发性肠淋巴瘤临床误诊率极高，肠镜检查及准确地活检有利于本病术前确诊。 Objective To study the pathological morphology and clinical features of primary intestinal non-Hodgkin’s lymphoma and analyze the causes of clinical misdiagnosis. Methods The clinical data of 20 cases of primary intestinal non-Hodgkin’s lymphoma were retrospectively analyzed, and routine pathological examination and partial immunohistochemical staining were performed. Results There were 13 males and 7 females in this group. The average age of 37.9 years old, 50% of 20-40 years old, the majority of the incidence of the colon and cecum, preoperative only 3 cases were diagnosed. The pathological classification included 6 cases of T-cells and 14 cases of B-cells, of which 2 cases were enteropathy-associated T-cell lymphomas and 4 cases were mucosa-associated B-cell lymphomas. Conclusion The rate of clinical misdiagnosis of primary intestinal lymphoma is extremely high. Colonoscopy and accurate biopsy are beneficial to the diagnosis of the disease.